Formulation Guideline
Sugar-free Vitamin C Chewable Tablets Using PEARLITOL® 200 SD Mannitol
Directly compressible formulation for sugar-free vitamin C chewable tablets
Formula
|
%(by weight)
|
mg / tablet
|
---|---|---|
PEARLITOL® 200 SD mannitol
|
63.950
|
480.00
|
Sodium ascorbate, granulated
|
21.350
|
160.00
|
Ascorbic acid, coated
|
12.000
|
90.00
|
Magnesium stearate
|
2.000
|
15.00
|
Orange powder flavor
|
0.300
|
2.25
|
AEROSIL® R972 silica*
|
0.300
|
2.25
|
Sodium saccharinate
|
0.050
|
0.37
|
Yellow coloring agent (E102)
|
0.009
|
0.07
|
Red coloring agent (E124)
|
0.008
|
0.06
|
Method
- Introduce in the mixer all the ingredients except the lubricant.
- Mix for 10 minutes.
- Add magnesium stearate.
- Mix again for 5 minutes.
- Compress the powder with 13 mm round flat face punches.
Additional comments
- Tablet weight: 750 mg
- Tablet thickness: 4.40 mm
- Tablet density: 1.288 g/cm3
- Tablet Hardness: 100 N
- Dosage: 250 mg vitamin C / 750 mg tablet
Disclaimer
This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s).
These details are for information only and we believe them to be reliable.
* AEROSIL®R972 is registered trademark of Evonik.