Sugar-free Aspirin Chewable Tablets Using PEARLITOL® 200 SD Mannitol
Formulation Guideline

Sugar-free Aspirin Chewable Tablets Using PEARLITOL® 200 SD Mannitol

Directly compressible formulation of chewable tablets containing Aspirin, a moisture-sensitive API

Formula

% (By weight)

mg / tablet

Aspirin

50.0

500

PEARLITOL® 200 SD mannitol

43.2

432

Stearic acid (< 80 μm) 80="">

2.5

25

Talc

2.0

20

Orange flavor, powder

1.5

15

Aspartame

0.5

5

AEROSIL® R972 silica*

0.3

3

Method

  1. Introduce in the mixer, the aspirin, silica, flavor and aspartame.
  2. Mix for 10 minutes.
  3. Add the talc and PEARLITOL® 200 SD; mix again for 5 minutes. 
  4. Add stearic acid and mix for 5 minutes.
  5. Compress the powder with round flat face punches of 13 mm diameter.

Additional comments

  • Tablet weight: 1000 mg 
  • Tablet thickness: 6.02 mm
  • Tablet density: 1.277 g/cm3
  •  Tablet Hardness: 87 N
  • Dosage: 500 mg / tablet

Disclaimer

This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s). 
These details are for information only and we believe them to be reliable.

*AEROSIL® R972 is the registered  trademark of Evonik

You may also like…

View all Inspiration
View all Inspiration

Request a Document

Entering your details below will send your query to the relevant team for a swift and helpful response. We will not use your details for anything other than replying to your query.

Product Details

Your Details


By giving your consent, you confirm that you have read the relevant Privacy Notice available here.

* Required fields

Request A Document

{Market}

Submit > {Product} > {Usage Country}