Formulation Guideline
Placebo Mint flavor Orodispersible Tablets with Mannitol
Directly compressible formulation for placebo orodispersible tablets (ODT)
Formula
|
% (by weight)
|
mg / tablet
|
---|---|---|
PEARLITOL® 200 SD mannitol
|
87.479
|
540.60
|
Crospovidone
|
10.000
|
61.8
|
Magnesium stearate
|
1.500
|
9.3
|
Caramel flavor, M52208 (Mane)
|
0.500
|
3.1
|
Vanilla flavor, M30313 (Mane)
|
0.500
|
3.1
|
Dualake FDC Yellow N°5 MD (Sensient)
|
0.020
|
0.12
|
Dualake FDC Yellow N°40 HD (Sensient)
|
0.001
|
0.006
|
Method
- In a mixer, mix PEARLITOL® 200 SD, crospovidone, flavors and colors for 10 minutes.
- Add magnesium stearate and mix for 5 minutes.
- Compress the powder with 13 mm flat face bevel edge punches.
Additional Comments
- Tablet weight: 620 mg
- Tablet thickness: 4.50 mm
- Tablet density: 1.032 g/cm3
- Tablet hardness: 40 N
Disclaimer
This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s).
These details are for information only and we believe them to be reliable.