Ginseng swallowable tablet formulation for direct compression
Directly compressible formulation of ginseng oral tablets using StarLac® co-processed lactose starch as filler-binder with disintegrant properties
Objective
Develop a prototype formulation for oral tablets of ginseng demonstrating the desirable flow and tabletability of StarLac® as a filler-binder with disintegrant properties for direct compression process.
Formula
|
Ingredient |
Functionality of the ingredient |
mg/tablet |
% by weight |
|
Ginseng powder |
Active ingredient |
67.0 |
10.0 |
|
StarLac® co-processed lactose starch |
Direct compression filler-binder and disintegrant |
599.7 |
89.5 |
|
Magnesium stearate |
Lubricant |
3.3 |
0.5 |
Method
1. In a mixer, mix StarLac® co-processed lactose starch with the ginseng powder for 5 minutes.
2. Add the magnesium stearate and mix for 5 minutes more.
3. Compress the powder with a 13 mm diameter concave punch.
Additional comments
|
Tablet hardness |
131 N |
|
Tablet density |
1.364 g/cm3 |
|
Tablet thickness |
5.45 mm |
|
Tablet mass |
670 mg |
Comment on Roquette product benefits
StarLac® co-processed lactose starch is a filler/binder having strong disintegrant properties. The co-processing offers superior benefit compared to a blend of lactose and starch, which allows you to improve the performance (hardness, friability, disintegration time) of your existing formulation. Specifically designed for direct compression applications, StarLac® is also an excellent filler/binder in dry granulation processes. StarLac® can be used in various oral dosage forms in both pharmaceutical and nutraceutical applications including granules, swallowable tablets, orally dispersible tablets and hard capsules.
StarLac® is EP/USP-NF compliant.
StarLac® is a product co-marketed by Meggle and Roquette. StarLac® is a registered trademark of Meggle AG.
Disclaimer
This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s).
These details are for information only, and we believe them to be reliable.