Formulation Guideline
Antacid Chewable Tablets using PEARLITOL® 160 C Mannitol (Wet Granulation)
Chewable antacid tablets produced via wet granulation containing PEARLITOL® 160 C Mannitol as filler and LYCATAB® DSH Maltodextrin as binder solution
Formula
|
|
% (By weight) |
mg / tablet |
|---|---|---|
|
PEARLITOL® 160 C mannitol |
70.90 |
567.2 |
|
Aluminium hydroxide Al2 (OH)6 |
20.00 |
160.0 |
|
Magnesium hydroxide Mg (OH)2 |
5.00 |
40.0 |
|
Magnesium stearate |
1.50 |
12.0 |
|
LYCATAB® DSH maltodextrin (in aqueous solution 10%, w/w) |
1.30 |
10.4 |
|
Buttermint flavor |
1.00 |
8.0 |
|
AEROSIL® R 972 silica* |
0.30 |
2.4 |
Method
- Introduce in the planetary mixer the PEARLITOL® 160 C mannitol.
- Slowly add the binder solution (LYCATAB® DSH maltodextrin).
- Mixing total time: 20 minutes.
- Introduce this wet mix in the granulator equipped with a wire mesh of 800 µm.
- Dry the granules in a fluidized air bed dryer for 60-70 oC for 30 minutes.
- Introduce all the ingredients except the lubricant in the mixer.
- Mix for 10 minutes.
- Add magnesium stearate and mix again for 5 minutes.
- Compress the powder to desired tablet shape, size and hardness.
Addional comments
- PEARLITOL® mannitol is used as a filler and filler/binder as well as a bulk sweetener. The PEARLITOL® range offers a unique blend of exceptional physical and chemical stability and no hygroscopicity. With great organoleptic, non-cariogenic and sugar-free properties, PEARLITOL® is suitable to be used in formulations addressing various patient populations including pediatric and diabetic.
- LYCATAB® DSH maltodextrin is a high-performance wet granulation binder. It is completely soluble in cold water and has excellent wettability. These characteristics make it a versatile excipient for most granulation equipment and for binder incorporation (in the dry mix or as a binder solution).
Disclaimer
This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s).
These details are for information only, and we believe them to be reliable.
*AEROSIL® is registered trademark of Evonik Industries or its subsidiaries.