Vitamin E Chewable Tablets Using PEARLITOL® 200 SD Mannitol and XYLISORB® 300 Xylitol

Vitamin E Chewable Tablets Using PEARLITOL® 200 SD Mannitol and XYLISORB® 300 Xylitol

Directly compressible formulation for vitamin E chewable tablets

Formula

% (by weight)
mg / tablet
PEARLITOL® 200 SD mannitol
43.93
659.0
XYLISORB® 300 xylitol
43.93
659.0
KLEPTOSE® βCD beta-cyclodextrin
7.67
115.0
DLα tocopherol acetate
1.67
25.0
Magnesium stearate
1.50
22.5
Mint flavor (Firmenich)
0.60
9.0
Citric acid
0.40
6.0
Lemon flavor (Firmenich)
0.30
4.5

Method

  1. Mix KLEPTOSE® βCD and water into a double jacket mixer heated to 50°C.
  2. Introduce tocopherol acetate and mix for 2 hours.
  3. Dry the mix in a drying oven at 45°C.
  4. Grind the dry complex KLEPTOSE® βCD / tocopherol acetate.
  5. Mix PEARLITOL® 200 SD, XYLISORB® 300, dry complex, citric acid and flavors for 5 minutes. 
  6. Add magnesium stearate and mix for 5 minutes.
  7. Compress the powder with 18 mm flat face punches.

Additional comments

  • Tablet weight: 1500 mg 
  • Tablet thickness: 4.70 mm
  • Tablet density: 1.25 g/cm3
  •  Tablet hardness: 80 N
  • Dosage: 25 mg vitamin E / 1500 mg tablet

Disclaimer

This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s). 
These details are for information only and we believe them to be reliable.