Sugar-free Aspirin Chewable Tablets Using PEARLITOL® 200 SD Mannitol
Formulation Guideline

Sugar-free Aspirin Chewable Tablets Using PEARLITOL® 200 SD Mannitol

Directly compressible formulation of chewable tablets containing Aspirin, a moisture-sensitive API

Formula

% (By weight)

mg / tablet

Aspirin

50.0

500

PEARLITOL® 200 SD mannitol

43.2

432

Stearic acid (< 80 μm) 80="">

2.5

25

Talc

2.0

20

Orange flavor, powder

1.5

15

Aspartame

0.5

5

AEROSIL® R972 silica*

0.3

3

Method

  1. Introduce in the mixer, the aspirin, silica, flavor and aspartame.
  2. Mix for 10 minutes.
  3. Add the talc and PEARLITOL® 200 SD; mix again for 5 minutes. 
  4. Add stearic acid and mix for 5 minutes.
  5. Compress the powder with round flat face punches of 13 mm diameter.

Additional comments

  • Tablet weight: 1000 mg 
  • Tablet thickness: 6.02 mm
  • Tablet density: 1.277 g/cm3
  •  Tablet Hardness: 87 N
  • Dosage: 500 mg / tablet

Disclaimer

This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s). 
These details are for information only and we believe them to be reliable.

*AEROSIL® R972 is the registered  trademark of Evonik