Placebo Orodispersible Tablets with PEARLITOL® 200 SD Mannitol
Formulation Guideline

Placebo Orodispersible Tablets with PEARLITOL® 200 SD Mannitol

Directly compressible formulation for placebo orodispersible tablets (ODT)

Formula

% (by weight)
mg / tablet
PEARLITOL® 200 SD mannitol
87.479
540.60
Crospovidone
10.000
61.8
Magnesium stearate
1.500
9.3
Caramel flavor, M52208 (Mane)
0.500
3.1
Vanilla flavor, M30313 (Mane)
0.500
3.1
Dualake FDC Yellow N°5 MD (Sensient)
0.020
0.12
Dualake FDC Yellow N°40 HD (Sensient)
0.001
0.006

Method

  1. In a mixer, mix PEARLITOL® 200 SD, crospovidone, flavors and colors for 10 minutes.
  2. Add magnesium stearate and mix for 5 minutes.
  3. Compress the powder with 13 mm flat face bevel edge punches.

Additional Comments

  • Tablet weight: 620 mg
  • Tablet thickness: 4.50 mm
  • Tablet density: 1.032 g/cm3
  •  Tablet hardness: 40 N

Disclaimer

This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s). 
These details are for information only and we believe them to be reliable.