Placebo Orodispersible Tablets using PEARLITOL® Flash Mannitol-Maize Starch Compound
Formulation Guideline

Placebo Orodispersible Tablets using PEARLITOL® Flash Mannitol-Maize Starch Compound

Placebo formulation for a directly compressible mint flavor orodispersible tablets (ODT)

Formula

% (By weight)

mg / tablet

PEARLITOL® Flash mannitol, starch

98.3

491.5

Mint flavor powder

1.0

5.0

Aspartame

0.3

1.5

Magnesium stearate

0.4

2.0

Method

  1. In a mixer, mix PEARLITOL® Flash, mint flavor and aspartame for 5 minutes.
  2. Add magnesium stearate and mix for 5 minutes.
  3. Compress the powder with 13 mm flat face bevel edge punches.

Additional comments

  • Tablet weight: 499.1 mg
  • Tablet thickness: 3.0 mm
  • Tablet density: 1.253 g/cm3
  •  Tablet hardness: 74 N
  • In vivo disintegration time: 35 s

Disclaimer

This formula is a guideline for recommended use of our products; it does not imply consent to their use in violation of existing patent(s). 
These details are for information only and we believe them to be reliable.