NUTRIOSE® Soluble Fiber Selectively Modulates Gut Microbiota Composition in Healthy Volunteers
The Science Behind

NUTRIOSE® Soluble Fiber Selectively Modulates Gut Microbiota Composition in Healthy Volunteers

Investigation on the impact of NUTRIOSE® soluble fiber on gut microbiota modulation in healthy volunteers.

Authors

     

Authors

L. GUERIN-DEREMAUX, ROQUETTE, Lestrem, France 

MR HOBDEN, University of Reading, Department of Food and Nutritional Sciences, Reading, UK  

C. ZHANG, SPRIM, Shanghai, China 

C. NEUT, College of Pharmacy, Clinical Bacteriology Laboratory, INSERM U995 LIRIC, Lille, France 

C. THABUIS
, ROQUETTE, Lestrem, France 

R. VAZHAPPILLY, ROQUETTE, Singapor   

GR GIBSON, University of Reading, Department of Food and Nutritional Sciences, Reading, UK 

OB KENNEDY, University of Reading, Department of Food and Nutritional Sciences, Reading, UK 

 

STUDY OBJECTIVES

  • In 2017, the International Scientific Association for Probiotics and Prebiotics (ISAPP) has defined a prebiotic as “a substrate that is selectively utilized by host microorganisms conferring a health benefit”. NUTRIOSE® is a soluble non-viscous fiber produced from wheat, maize or pea starch with supporting science showing that this fiber is slightly digested in the small intestine and progressively fermented all along the colon. 
    The objective of the present research was to investigate the impact of NUTRIOSE® soluble fiber on gut microbiota modulation in healthy volunteers.

METHODS

Study 1

   Healthy volunteers
 n=12/group
 France
   14 Days
   Daily intake:

- 20g glucose (control)

- 10.15 or 20g NUTRIOSE®
   Fecal microbiota using culture methods                           
 

Study 2

  Healthy volunteers
n=20/group
France 
   14 Days
   Daily intake:
- 8g glucose (control)
- 8g NUTRIOSE®
   Fecal microbiota using real-time PCR analysis               
 

Study 3

  Healthy volunteers
n=20 normal weight
n=16 overweight
United Kingdom
   28 Days
   Daily intake:
- 7g maltodextrin (control)
- 14g NUTRIOSE®
 

 Fecal microbiota using using fluorescence in situhybridization & 16S rRNA sequencing

Results

Bacteroides

 

 

 Fig. 1: Fecal Bacteroides
Significant increase in the saccharolytic bacteria following the administration of 10g/day (study 1) or 8g/day (study 2) of NUTRIOSE® compared to baseline.
 

Clostridium cluster IX

Fig. 3: Fecal Clostridium cluster IX
Significant increase in a propionate producing bacterial group.

Clostridium perfringes

Fig. 2: Fecal Clostridium perfringens
Significant decrease following the administration of 15g/day (study 1) or 8g/day (study 2) of NUTRIOSE® compared to baseline.

 
Relative bacterial abundance

 Fig. 4: Fecal relative abundance
Significant increase in the saccharolytic Parabacteroides genus, a Bacteroides subgroup of the phylum Bacteroidetes.

 

CONCLUSIONS

NUTRIOSE® supplementation selectively modulates gut microbiota to a healthier composition. Previously, several studies have demonstrated the health benefits of NUTRIOSE® in blood glucose management, digestive health and sustained energy release. Many of these health benefits produced by NUTRIOSE® were thought to be driven by the selective modulation of the gut microbiota. Collectively all these results show that NUTRIOSE® meets the requirement of the definition of a prebiotic as defined by ISAPP. NUTRIOSE® soluble fiber can be considered as an emerging prebiotic.

DISCLAIMER

FENS 2019 – 13th European Nutrition Conference – October 2019 – Ireland 

The information contained in this document is to the best of our knowledge true and accurate, but all instructions, recommendations or suggestions are made without guarantee. Since the conditions of use are beyond our control, we disclaim any liability for loss and/or damage suffered from use of these data or suggestions. Furthermore, no liability is accepted if use of any product in accordance with these data or suggestions infringes any patent. No part of this document may be reproduced by any process without our prior written permission. 

© Roquette Frères S.A. - FENS - 09/2019 

 

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