NUTRIOSE®, a Soluble Fiber with Demonstrated Benefits for Blood Glucose Management in Humans

Authors

L. GUERIN-DEREMAUX, Roquette, Lestrem, France 

MR HOBDEN, University of Reading, Department of Food and Nutritional Sciences, Reading, UK 

C. THABUIS, Roquette, Lestrem, France 

R. VAZHAPPILLY, Roquette, Singapore  

K. MORTON, QPS Bio-Kinetic, Springfield, USA  

D. KALMAN, QPS Bio-Kinetic, Springfield, US 

OB KENNEDY, University of Reading, Department of Food and Nutritional Sciences, Reading, UK 

STUDY OBJECTIVES

ROQUETTE has developed solutions contributing to the prevention of major health concerns worldwide. Among these solutions, NUTRIOSE® is a soluble non-viscous produced from wheat or maize starch with a fibre content of 85% (on D.S).

The objectives of the present research were to demonstrate in healthy volunteers that NUTRIOSE® displayed positive effects on blood glucose management, with: 

• a low glycaemic response, 
• a beneficial impact on glucose response when incorporated in a powder mix beverage,
• a long term attenuation of blood glucose spikes following a carbohydrates challenge.

METHODS

Short-term impact of NUTRIOSE® on glucose response – Study 1

• Cross-over study (Eurofins Optimed)
• Healthy volunteers (n=6)
• 50g intake of NUTRIOSE® or glucose
• 1-day study

Short-term impact of NUTRIOSE® incorporation in a beverage on glucose response – Study 2

• Cross-over study (QPS Bio-Kinetic)
• Healthy volunteers (n=30)
• 30g intake of powder mix beverage containing NUTRIOSE® dissolved in 300ml of water or a control powder mix beverage
• 1-day study

Table 1: Composition of the powder mix beverages

Long-term glucose blunting impact of NUTRIOSE® - Study 3

• Cross-over study (University of Reading)
• Normal weight (n=20) and overweight (n=16) volunteers
• 14g/day of NUTRIOSE® or an energy-matched placebo as a mid-morning and mid-afternoon drinks
• 28-day study

RESULTS

Short-term impact of NUTRIOSE® on glucose response 

Fig. 1: Evolution of Glycaemia after product intake

• Glycaemic response of NUTRIOSE®: 25%
• Insulinaemic response of NUTRIOSE® : 13% (data not shown)

Short-term impact of NUTRIOSE® incorporation in a beverage on glucose response

Fig. 2: Evolution of Glycaemia after product intake

• Significant reduction of the glycaemic impact of the fibre beverage
• Glycaemic response of the NUTRIOSE®-based beverage: 64%
• Insulinaemic response of the NUTRIOSE®-based beverage: 42% (data not shown)

 Fig. 3: Evolution of glycaemia after carbohydrates challenge

• After 14 and 28 days of NUTRIOSE® consumption, attenuation of the maximum blood glucose concentration following orange juice intake
• AUC (from 0 to 30 min) different at day 14 and 28 between groups (p<0.05) and within the NUTRIOSE® group over time (p<0.05)

CONCLUSIONS

NUTRIOSE® soluble fibre is a good candidate for sugar reduction and improvement of food products fibre content. And more interestingly, this fibre may be used as an integrated solution for better blood glucose management as NUTRIOSE® helps maintaining healthy blood glucose levels and controls fluctuations in blood glucose after a preload rich in carbohydrates.

LIST OF REFERENCES

(1): Lefranc et al., 2015, 6th international dietary fibre conference  

(2): Li et al., 2010, Appl Physiol Nutr Metab  

(3): Aliasgharzadeh et al., 2015, Br J Nutr 

DISCLAIMER

7th International Dietary Fibre Conference 2018 - June 2018 - The Netherlands 

The information contained in this document is to the best of our knowledge true and accurate, but all instructions, recommendations or suggestions are made without guarantee. Since the conditions of use are beyond our control, we disclaim any liability for loss and/or damage suffered from use of these data or suggestions. Furthermore, no liability is accepted if use of any product in accordance with these data or suggestions infringes any patent. No part of this document may be reproduced by any process without our prior written permission.  

© Roquette Frères S.A. - 05/2018